2024
Bazilio DS, Moraes DJA, Machado BH. Glutamatergic and purinergic transmitters and astrocyte modulation in the synaptic transmission in the NTS of rats exposed to short-term sustained hypoxia. Am J Physiol Regul Integr Comp Physiol. 2024 Aug 5. doi: 10.1152/ajpregu.00293.2023. Epub ahead of print. PMID: 39102465.
Souza JR, Lima-Silveira L, Accorsi-Mendonça D, Machado BH. Enhancement of the Evoked Excitatory Transmission in the Nucleus Tractus Solitarius Neurons after Sustained Hypoxia in Mice Depends on A2A Receptors. Neuroscience. 2024 Jan 9;536:57-71. doi: 10.1016/j.neuroscience.2023.11.010.
2023:
Souza JR, Machado BH. Cardiovascular and respiratory evaluation in adenosine A2A receptor knockout mice submitted to short-term sustained hypoxia. Exp Physiol. 2023 Nov; 108(11): 1434-1445. doi: 10.1113/EP091221.
Machado BH. Evidence that sympathetic overactivity and neurogenic hypertension correlate with changes in the respiratory pattern in rodent models of experimental hypoxia. Adv Exp Med Biol. 2023; 1427: 23-33. doi: 10.1007/978-3-031-32371-3_3.
Felippe ISA, Río RD, Schultz H, Machado BH, Paton JFR. Commonalities and differences in carotid body dysfunction in hypertension and heart failure. J Physiol. 2023 Sep 25. doi: 10.1113/JP284114.
2022:
Paton JFR, Machado BH, Moraes DJA, Zoccal DB, Abdala AP, Smith JC, Antunes VR, Murphy D, Dutschmann M, Dhingra RR, McAllen R, Pickering AE, Wilson RJA, Day TA, Barioni NO, Allen AM, Menuet C, Donnelly J, Felippe I, St-John WM. Advancing respiratory-cardiovascular physiology with the working heart-brainstem preparation over 25 years. J Physiol. 2022 Mar 16. doi: 10.1113/JP281953.
Souza JR, Oliveira M, Machado BH. Sustained hypoxia in mice increases parasympathetic but not sympathetic tone. Curr Res Physiol. 2022 Sep 21; 5: 361-368. doi: 10.1016/j.crphys.2022.09.006.
2021:
Magalhães KS, da Silva MP, Mecawi AS, Paton JFR, Machado BH, Moraes DJA. Intrinsic and synaptic mechanisms controlling the expiratory activity of excitatory lateral parafacial neurones of rats. J Physiol. 2021 Nov; 599(21): 4925-4948. doi: 10.1113/JP281545.
Machado BH, Paton JFR. Relevance of carotid bodies in COVID-19: A hypothetical viewpoint. Auton Neurosci. 2021 Apr 17; 233: 102810. doi: 10.1016/j.autneu.2021.102810.
Rodrigues KL, Souza JR, Bazilio DS, de Oliveira M, Moraes MPS, Moraes DJA, Machado BH. Changes in the autonomic and respiratory patterns in mice submitted to short-term sustained hypoxia. Exp Physiol. 2021 Jan 27. doi: 10.1113/EP089323.
Pascoaloti-Lima JC, Machado BH, Accorsi-Mendonça D. Sustained hypoxia reduces GABAergic modulation on NTS neurons sending projections to ventral medulla of rats. Neuroscience. 2021 Jan 7: S0306-4522(20)30813-7. doi: 10.1016/j.neuroscience.2020.12.028
Bazilio DS, Rodrigues KL, Moraes DJA, Machado BH. Distinct cardiovascular and respiratory responses to short-term sustained hypoxia in juvenile Sprague Dawley and Wistar Hannover rats. Auton Neurosci. 2021 Jan; 230:102746. doi: 10.1016/j.autneu.2020.102746.
2020:
Bazilio DS, Moraes DJA, Machado BH. Active expiration and chronic intermittent hypoxia-induced hypertension: A hypothesis that still breathes! Exp Physiol. 2020 Feb; 105(2): 393-394. doi: 10.1113/EP088.
2019:
Zoccal DB, Colombari DSA, Colombari E, Flor KC, da Silva MP, Costa-Silva JH, Machado BH, Moraes DJA, Murphy D, Paton JFR. Centrally acting adrenomedullin in the long-term potentiation of sympathetic vasoconstrictor activity induced by intermittent hypoxia in rats. Exp Physiol. 2019 Sep; 104(9): 1371-1383. doi: 10.1113/EP087613.
Lima-Silveira L, Accorsi-Mendonça D, Bonagamba LGH, Almado CEL, da Silva MP, Nedoboy PE, Pilowsky PM, Machado BH. Enhancement of excitatory transmission in NTS neurons projecting to ventral medulla of rats exposed to sustained hypoxia is blunted by minocycline. J Physiol. 2019 Jun; 597(11): 2903-2923. doi: 10.1113/JP277532.
Bazilio DS, Bonagamba LGH, Moraes DJA, Machado BH. Cardiovascular and respiratory profiles during the sleep-wake cycle of rats previously submitted to chronic intermittent hypoxia. Exp Physiol. 2019 Sep; 104(9): 1408-1419. doi: 10.1113/EP087784.
Accorsi-Mendonça D, Bonagamba LGH, Machado BH. Astrocytic modulation of glutamatergic synaptic transmission is reduced in NTS of rats submitted to short-term sustained hypoxia. J Neurophysiol. 2019 May 1; 121(5): 1822-1830. doi: 10.1152/jn.00279.2018.
Souza GMPR, Barnett WH, Amorim MR, Lima-Silveira L, Moraes DJA, Molkov YI, Machado BH. Pre- and post-inspiratory neurons change their firing properties in female rats exposed to chronic intermittent hypoxia. Neuroscience. 2019 May 15; 406: 467-486. doi: 10.1016/j.neuroscience.2019.03.043.
da Silva MP, Moraes DJA, Bonagamba LGH, Mecawi AS, Varanda WA, Machado BH. Hyperexcitability and plasticity induced by sustained hypoxia on rectus abdominis motoneurons. J Physiol. 2019 Apr; 597(7): 1935-1956. doi: 10.1113/JP277030.
Amorim MR, Pena RFO, Souza GMPR, Bonagamba LGH, Roque AC, Machado BH. Firing properties of ventral medullary respiratory neurons in sino-aortic denervated rats. Exp Physiol. 2019 Jan; 104(1): 39-49. doi: 10.1113/EP087150.
2018:
Souza GMPR, Amorim MR, Moraes DJA, Machado BH. Sex differences in the respiratory-sympathetic coupling in rats exposed to chronic intermittent hypoxia. Respir Physiol Neurobiol. 2018. 256:109-118. doi: 10.1016/j.resp.2017.09.003.
Moraes DJA, da Silva MP, Spiller PIPF, Machado BH, Paton JFR. Purinergic plasticity within petrosal neurons in hypertension. Am J Physiol Regul Integr Comp Physiol. 2018. Nov 1; 315(5): R963-R971. doi: 10.1152/ajpregu.00142.2018.
Perim RR, Amorim MR, Bonagamba LGH, Machado BH. Previous exposure to chronic intermittent hypoxia blunts the development of one-kidney one-clip hypertension in rats. Exp Physiol. 2018. 103(4): 473-482. doi: 10.1113/EP087150.
Amorim MR, Souza GMPR, Machado BH. Possible Breathing Influences on the Control of Arterial Pressure After Sino-aortic Denervation in Rats. Curr Hypertens Rep. 2018 Jan 22; 20(1): 2. doi: 10.1007/s11906-018-0800-3.
2017:
Moraes DJA, Bonagamba LGH, da Silva MP, Paton JFR, Machado BH. Role of ventral medullary catecholaminergic neurons for respiratory modulation of sympathetic outflow in rats. Sci Rep. 2017. 7(1): 16883. doi: 10.1038/s41598-017-17113-7.
Amorim MR, Bonagamba LGH, Souza GMPR, Moraes DJA, Machado BH. Changes in the inspiratory pattern contribute to modulate the sympathetic activity in sino-aortic denervated rats. Exp Physiol. 2017. 102(9):1100-1117.doi: 10.1113/EP086353
Machado BH, Zoccal DB, Moraes DJA. Neurogenic Hypertension and the Secrets of Respiration. Am J Physiol Regul Integr Comp Physiol. 2017. 312(6): R864-R872.doi: 10.1152/ajpregu.00505.2016.
Przygodda F, Manfredi LH, Machado J, Gonçalves DAP, Zanon NM, Bonagamba LGH, Machado BH, Kettelhu IC, Navegantes LCC. Acute intermittent hypoxia in rats activates muscle proteolytic pathways through a gluccorticoid-dependent mechanism. J Appl Physiol (1985). 2017. 122(5): 1114-1124. doi: 10.1152/japplphysiol.00977.2015.
2016:
Souza GMPR, Bonagamba LG, Amorim MR, Moraes DJ, Machado BH. Inspiratory modulation of sympathetic activity is increased in female rats exposed to chronic intermittent hypoxia. Exp Physiol. 2016. 101(11): 1345-1358. doi: 10.1113/EP085850.
Amorim MR, Bonagamba LG, Souza GMPR, Moraes DJ, Machado BH. Role of respiratory changes in the modulation of arterial pressure in rats submitted to sino-aortic denervation. Exp Physiol. 2016. 01(11): 1359-1370. doi: 10.1113/EP085897.
Accorsi-Mendonça D, da Silva MP, Souza GMPR, Lima-Silveira L, Karlen-Amarante M, Amorim MR, Almado CE, Moraes DJ, Machado BH. Pacemaking Property of RVLM Presympathetic Neurons. Front Physiol. 2016. 7:424. doi: 10.3389/fphys.2016.00424.
Erratum in Front Physiol. 2016 Nov 23; 7:575. doi: 10.3389/fphys.2016.00575. eCollection 2016.
Pijacka W, Moraes DJ, Ratcliffe LE, Nightingale AK, Hart EC, da Silva MP, Machado BH, McBryde FD, Abdala AP, Ford AP, Paton JF. Purinergic receptors in the carotid body as a new drug target for controlling hypertension. Nature Medicine. 2016. 22(10):1151-1159. doi: 10.1038/nm.4173
Moraes DJ, Bonagamba LG, da Silva MP, Mecawi AS, Antunes-Rodrigues J, Machado BH. Respiratory Network Enhances the Sympathoinhibitory Component of Baroreflex of Rats Submitted to Chronic Intermittent Hypoxia. Hypertension. 2016. 68(4):1021-30. doi: 10.1161/HYPERTENSIONAHA.116.07731.
2015:
Drager LF, Polotsky VY, O'Donnell CP, Cravo SL, Lorenzi-Filho G, Machado BH. Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea. Am J Physiol Heart Circ Physiol. 2015 Oct; 309(7): H1101-11. doi: 10.1152/ajpheart.00094.2015.
Perim RR, Bonagamba LG, Machado BH. Cardiovascular and respiratory outcome of preconditioned rats submitted to chronic intermittent hypoxia. Exp Physiol. 2015 Sep; 100(9): 1008-17. doi: 10.1113/EP085237.
Moraes DJ, Machado BH, Paton JF. Carotid body overactivity induces respiratory neurone channelopathy contributing to neurogenic hypertension. J Physiol. 2015 Jul 15; 593(14): 3055-63. doi: 10.1113/JP270423.
Accorsi-Mendonça D, Almado CE, Bonagamba LG, Castania JA, Moraes DJ, Machado BH. Enhanced Firing in NTS Induced by Short-Term Sustained Hypoxia Is Modulated by Glia-Neuron Interaction. J Neurosci. 2015 Apr 29; 35(17): 6903-17. doi: 10.1523/JNEUROSCI.4598-14.2015.
Souza GMPR, Bonagamba LG, Amorim MR, Moraes DJ, Machado BH. Cardiovascular and respiratory responses to chronic intermittent hypoxia in adult female rats. Exp Physiol. 2015 Mar; 100(3): 249-58. doi: 10.1113/expphysiol.2014.082990.
Moraes DJ, Machado BH. Electrophysiological properties of laryngeal motoneurones in rats submitted to chronic intermittent hypoxia. J Physiol. 2015 Feb 1; 593(3): 619-34. doi: 10.1113/jphysiol.2014.283085.
2014:
Costa KM, Accorsi-Mendonça D, Moraes DJ, Machado BH. Evolution and physiology of neural oxygen sensing. Front Physiol. 2014 Aug 12; 5: 302. doi: 10.3389/fphys.2014.00302.
Almado CE, Leão RM, Machado BH. Intrinsic properties of rostral ventrolateral medulla presympathetic and bulbospinal respiratory neurons of juvenile rats are not affected by chronic intermittent hypoxia. Exp Physiol. 2014 Jul; 99(7): 937-50. doi: 10.1113/expphysiol.2013.077800.
Granjeiro É, Marroni SS, Martins Dias DP, Heck Bonagamba LG, Costa KM, dos Santos JC, Oliveira JA, Machado BH, Garcia-Cairasco N. Behavioral and cardiorespiratory responses to bilateral microinjections of oxytocin into the central nucleus of amygdala of Wistar rats, an experimental model of compulsion. PLoS One. 2014 Jul 18; 9(7): e99284. doi: 10.1371/journal.pone.0099284.
Moraes DJ, Machado BH, Paton JF. Specific respiratory neuron types have increased excitability that drive presympathetic neurones in neurogenic hypertension. Hypertension. 2014 Jun; 63(6): 1309-18. doi: 10.1161/HYPERTENSIONAHA.113.02283.
Moraes DJ, Bonagamba LG, Costa KM, Costa-Silva JH, Zoccal DB, Machado BH. Short-term sustained hypoxia induces changes in the coupling of sympathetic and respiratory activities in rats. J Physiol. 2014 May 1; 592(9): 2013-33. doi: 10.1113/jphysiol.2013.262212.
Moraes DJ, Machado BH, Zoccal DB. Coupling of respiratory and sympathetic activities in rats submitted to chronic intermittent hypoxia. Prog Brain Res. 2014 212: 25-38. doi: 10.1016/B978-0-444-63488-7.00002-1.
Molkov YI, Zoccal DB, Baekey DM, Abdala AP, Machado BH, Dick TE, Paton JF, Rybak IA. Physiological and pathophysiological interactions between the respiratory central pattern generator and the sympathetic nervous system. Prog Brain Res. 2014; 212: 1-23. doi: 10.1016/B978-0-444-63488-7.00001-X.
2013:
Machado BH. Central control of autonomic and respiratory functions in health and diseases. Auton Neurosci. 2013 Apr; 175(1-2): 1-2. doi: 10.1016/j.autneu.2013.01.008.
Accorsi-Mendonça D, Machado BH. Synaptic transmission of baro- and chemoreceptors afferents in the NTS second order neurons. Auton Neurosci. 2013 Apr; 175(1-2): 3-8. doi: 10.1016/j.autneu.2012.12.002.
Costa KM, Moraes DJ, Machado BH. Acute inhibition of glial cells in the NTS does not affect respiratory and sympathetic activities in rats exposed to chronic intermittent hypoxia. Brain Res. 2013 Feb 16; 1496:36-48. doi: 10.1016/j.brainres.2012.12.003.
Accorsi-Mendonça D, Zoccal DB, Bonagamba LG, Machado BH. Glial cells modulate the synaptic transmission of NTS neurons sending projections to ventral medulla of Wistar rats. Physiol Rep. 2013 Sep; 1(4): e00080. doi: 10.1002/phy2.80.
Busnardo C, Ferreira-Junior NC, Cruz JC, Machado BH, Correa FM, Resstel LB. Cardiovascular responses to ATP microinjected into the paraventricular nucleus are mediated by nitric oxide and NMDA glutamate receptors in awake rats. Exp Physiol. 2013 Oct; 98(10): 1411-21. doi: 10.1113/expphysiol.2013.073619.
Moraes DJ, da Silva MP, Bonagamba LG, Mecawi AS, Zoccal DB, Antunes-Rodrigues J, Varanda WA, Machado BH. Electrophysiological properties of rostral ventrolateral medulla presympathetic neurons modulated by the respiratory network in rats. J Neurosci. 2013 Dec 4; 33(49): 19223-37. doi: 10.1523/JNEUROSCI.3041-13.2013.
2012:
Moraes DJ, Zoccal DB, Machado BH. Sympathoexcitation during chemoreflex active expiration is mediated by L-glutamate in the RVLM/Bötzinger complex of rats. J Neurophysiol. 2012 Jul; 108(2): 610-23. doi: 10.1152/jn.00057.2012.
Moraes DJ, Zoccal DB, Machado BH. Medullary respiratory network drives sympathetic overactivity and hypertension in rats submitted to chronic intermittent hypoxia. Hypertension. 2012 Dec; 60(6): 1374-80. doi: 10.1161/HYPERTENSIONAHA.111.189332.
Costa-Silva JH, Zoccal DB, Machado BH. Chronic intermittent hypoxia alters glutamatergic control of sympathetic and respiratory activities in the commissural NTS of rats. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 15; 302(6): R785-93. doi: 10.1152/ajpregu.00363.2011.
Moraes DJ, Dias MB, Cavalcanti-Kwiatkoski R, Machado BH, Zoccal DB. Contribution of the retrotrapezoid nucleus/parafacial respiratory region to the expiratory-sympathetic coupling in response to peripheral chemoreflex in rats. J Neurophysiol. 2012 Aug 1; 108(3): 882-90. doi: 10.1152/jn.00193.2012.
Almado CE, Machado BH, Leão RM. Chronic intermittent hypoxia depresses afferent neurotransmission in NTS neurons by a reduction in the number of active synapses. J Neurosci. 2012 Nov 21; 32(47): 16736-46. doi: 10.1523/JNEUROSCI.2654-12.2012.
2011:
Zoccal DB, Machado BH. Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension. Curr Hypertens Rep. 2011 Jun; 13(3): 229-36. doi: 10.1007/s11906-011-0198-7.
Zoccal DB, Huidobro-Toro JP, Machado BH. Chronic intermittent hypoxia augments sympatho-excitatory response to ATP but not to L-glutamate in the RVLM of rats. Auton Neurosci. 2011 Dec 7; 165(2): 156-62. doi: 10.1016/j.autneu.2011.06.001.
Accorsi-Mendonça D, Castania JA, Bonagamba LG, Machado BH, Leão RM. Synaptic profile of nucleus tractus solitarius neurons involved with the peripheral chemoreflex pathways. Neuroscience. 2011 Dec 1; 197: 107-20. doi: 10.1016/j.neuroscience.2011.08.054.
Molkov YI, Zoccal DB, Moraes DJ, Paton JF, Machado BH, Rybak IA. Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats. J Neurophysiol. 2011 Jun; 105(6): 3080-91. doi: 10.1152/jn.00070.2011.
Moraes DJ, Bonagamba LG, Zoccal DB, Machado BH. Modulation of respiratory responses to chemoreflex activation by L-glutamate and ATP in the rostral ventrolateral medulla of awake rats. Am J Physiol Regul Integr Comp Physiol. 2011 Jun; 300(6):R1476-86. doi: 10.1152/ajpregu.00825.2010.
Machado BH. Frontiers in Research Review: Stress and Hypertension. Clin Exp Pharmacol Physiol. 2011 Feb; 38(2): 113-4. doi: 10.1111/j.1440-1681.2010.05475.x.
2010:
Cruz JC, Bonagamba LG, Machado BH. Modulation of arterial pressure by P2 purinoceptors in the paraventricular nucleus of the hypothalamus of awake rats. Auton Neurosci. 2010 Dec 8; 158(1-2): 79-85. doi: 10.1016/j.autneu.2010.06.012.
Oliva WM, Granjeiro EM, Bongamba LG, Mendes RA, Machado BH. Dopamine microinjected into brainstem of awake rats affects baseline arterial pressure but not chemoreflex responses. Auton Neurosci. 2010 Jun 24; 155(1-2): 73-81. doi: 10.1016/j.autneu.2010.01.013.
Costa-Silva JH, Zoccal DB, Machado BH. Glutamatergic antagonism in the NTS decreases post-inspiratory drive and changes phrenic and sympathetic coupling during chemoreflex activation. J Neurophysiol. 2010 Apr; 103(4): 2095-106. doi: 10.1152/jn.00802.2009.
Zoccal DB, Machado BH. Sympathetic overactivity coupled with active expiration in rats submitted to chronic intermittent hypoxia. Respir Physiol Neurobiol. 2010 Nov 30; 174(1-2): 98-101. doi: 10.1016/j.resp.2010.08.011.
Cruz Jde C, Bonagamba LG, Stern JE, Machado BH. Fos expression in the NTS in response to peripheral chemoreflex activation in awake rats. Auton Neurosci. 2010 Jan 15; 152(1-2): 27-34. doi: 10.1016/j.autneu.2009.08.016.
Machado BH, Moraes DJ, Costa KM. Highlights in basic autonomic neurosciences: glia and neuromodulation. Auton Neurosci. 2010 156: 1-4.
2009:
Zoccal DB, Paton JF, Machado BH. Do changes in the coupling between respiratory and sympathetic activities contribute to neurogenic hypertension? Clin Exp Pharmacol Physiol. 2009 Dec; 36(12): 1188-96. doi: 10.1111/j.1440-1681.2009.05202.x.
Abdala AP, Rybak IA, Smith JC, Zoccal DB, Machado BH, St-John WM, Paton JF. Multiple pontomedullary mechanisms of respiratory rhythmogenesis. Respir Physiol Neurobiol. 2009 Aug 31; 168(1-2): 19-25. doi: 10.1016/j.resp.2009.06.011.
Machado BH. Frontiers in research reviews: in vitro approaches to the study of neural control of autonomic and respiratory functions. Introduction. Clin Exp Pharmacol Physiol. 2009 Dec; 36(12): 1186-7. doi: 10.1111/j.1440-1681.2009.05321.x.
Machado BH. IV Miguel R. Covian Symposium: new challenges for physiologists. Braz J Med Biol Res. 2009 Jan; 42(1): 1-2.
Granjeiro EM, Pajolla GP, Accorsi-Mendonça D, Machado BH. Interaction of purinergic and nitrergic mechanisms in the caudal nucleus tractus solitarii of rats. Auton Neurosci. 2009 Dec 3; 151(2): 117-26. doi: 10.1016/j.autneu.2009.07.022.
Pajolla GP, Accorsi-Mendonça D, Rodrigues GJ, Bendhack LM, Machado BH, Lunardi CN. Fluorescent indication that nitric oxide formation in NTS neurons is modulated by glutamate and GABA. Nitric Oxide. 2009 May; 20(3): 207-16. doi: 10.1016/j.niox.2009.01.001.
Zoccal DB, Bonagamba LG, Paton JF, Machado BH. Sympathetic-mediated hypertension of awake juvenile rats submitted to chronic intermittent hypoxia is not linked to baroreflex dysfunction. Exp Physiol. 2009 Sep; 94(9): 972-83. doi: 10.1113/expphysiol.2009.048306.
Accorsi-Mendonça D, Bonagamba LG, Leão RM, Machado BH. Are L-glutamate and ATP cotransmitters of the peripheral chemoreflex in the rat nucleus tractus solitarius? Exp Physiol. 2009 Jan; 94(1): 38-45. doi: 10.1113/expphysiol.2008.043653.
Cruz JC, Machado BH. GABA and nitric oxide in the PVN are involved in arterial pressure control but not in the chemoreflex responses in rats. Auton Neurosci. 2009 Mar 12; 146(1-2): 47-55. doi: 10.1016/j.autneu.2008.11.011.
Pajolla GP, Accorsi-Mendonça D, Lunardi CN, Bendhack LM, Machado BH, Llewellyn-Smith IJ. Immunoreactivity for neuronal NOS and fluorescent indication of NO formation in the NTS of juvenile rats submitted to chronic intermittent hypoxia. Auton Neurosci. 2009 Jun 15; 148(1-2): 55-62. doi: 10.1016/j.autneu.2009.03.003.
Granjeiro EM, Machado BH. NO in the caudal NTS modulates the increase in respiratory frequency in response to chemoreflex activation in awake rats. Respir Physiol Neurobiol. 2009 Mar 31; 166(1): 32-40. doi: 10.1016/j.resp.2009.01.003.
Machado BH. Neurotransmission of the peripheral chemoreflex in the nucleus tractus solitarii of unanesthetized experimental models. Tzu Chi Me J 2009 21: 6-11.
2008:
Braccialli AL, Bonagamba LG, Machado BH. Glutamatergic and purinergic mechanisms on respiratory modulation in the caudal NTS of awake rats. Respir Physiol Neurobiol. 2008 May 31; 161(3): 246-52. doi: 10.1016/j.resp.2008.02.011.
Accorsi-Mendonça D, Bonagamba LG, Leão RM, Machado BH. Are L-glutamate and ATP cotransmitters of the peripheral chemoreflex in the rat nucleus tractus solitarius? Exp Physiol. 2009 Jan; 94(1): 38-45. doi: 10.1113/expphysiol.2008.043653.
Zoccal DB, Simms AE, Bonagamba LG, Braga VA, Pickering AE, Paton JF, Machado BH. Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity. J Physiol. 2008 Jul 1; 586(13): 3253-65. doi: 10.1113/jphysiol.2008.154187.
Accorsi-Mendonça D, Almado CE, Dagostin AL, Machado BH, Leão RM. Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors. Brain Res. 2008 Mar 20; 1200: 1-9. doi: 10.1016/j.brainres.2008.01.011.
Benedetti M, Rorato R, Castro M, Machado BH, Antunes-Rodrigues J, Elias LL. Water deprivation increases Fos expression in hypothalamic corticotropin-releasing factor neurons induced by right atrial distension in awake rats. Am J Physiol Regul Integr Comp Physiol. 2008 Nov; 295(5): R1706-12. doi: 10.1152/ajpregu.00022.2008.
Cruz JC, Bonagamba LG, Machado BH, Biancardi VC, Stern JE. Intermittent activation of peripheral chemoreceptors in awake rats induces Fos expression in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus. Neuroscience. 2008 Nov 19; 157(2): 463-72. doi: 10.1016/j.neuroscience.2008.08.070.
Machado BH. Prospect of Biomedical Research in Developing Countries. Al Ameen J Med Res 2008 1: 64.
2007:
Zoccal DB, Bonagamba LG, Oliveira FR, Antunes-Rodrigues J, Machado BH. Increased sympathetic activity in rats submitted to chronic intermittent hypoxia. Exp Physiol. 2007 Jan;92(1): 79-85. doi: 10.1113/expphysiol.2006.035501.
Salgado HC, Barale AR, Castania JA, Machado BH, Chapleau MW, Fazan R Jr. Baroreflex responses to electrical stimulation of aortic depressor nerve in conscious SHR. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1): H593-600. doi: 10.1152/ajpheart.00181.2006.
Damaso EL, Bonagamba LG, Kellett DO, Jordan D, Ramage AG, Machado BH. Involvement of central 5-HT7 receptors in modulation of cardiovascular reflexes in awake rats. Brain Res. 2007 May 4; 1144: 82-90. doi: 10.1016/j.brainres.2007.01.088.
Braga VA, Zoccal DB, Soriano RN, Antunes VR, Paton JF, Machado BH, Nalivaiko E. Activation of peripheral chemoreceptors causes positive inotropic effects in a working heart-brainstem preparation of the rat. Clin Exp Pharmacol Physiol. 2007 Nov; 34(11): 1156-9. doi: 10.1111/j.1440-1681.2007.04699.x.
Silva de Oliveira LC, Bonagamba LG, Machado BH. Noradrenergic inhibitory modulation in the caudal commissural NTS of the pressor response to chemoreflex activation in awake rats. Auton Neurosci. 2007 Oct 30; 136(1-2): 63-8. doi: 10.1016/j.autneu.2007.04.004.
Braga VA, Paton JF, Machado BH. Ischaemia-induced sympathoexcitation in spinalyzed rats. Neurosci Lett. 2007 Mar 19; 415(1): 73-6. doi: 10.1016/j.neulet.2006.12.045.
Accorsi-Mendonça D, Leão RM, Aguiar JF, Varanda WA, Machado BH. Urethane inhibits the GABAergic neurotransmission in the nucleus of the solitary tract of rat brain stem slices. Am J Physiol Regul Integr Comp Physiol. 2007 Jan; 292(1): R396-402. doi: 10.1152/ajpregu.00776.2005.
Braga VA, Soriano RN, Braccialli AL, de Paula PM, Bonagamba LG, Paton JF, Machado BH. Involvement of L-glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart-brainstem preparation. J Physiol. 2007 Jun 15; 581(Pt 3): 1129-45. doi: 10.1113/jphysiol.2007.129031.
Zoccal DB, Bonagamba LG, Antunes-Rodrigues J, Machado BH. Plasma corticosterone levels is elevated in rats submitted to chronic intermittent hypoxia. Auton Neurosci. 2007 Jul 31; 134(1-2): 115-7. doi: 10.1016/j.autneu.2007.01.004.
Weissheimer KV, Machado BH. Inhibitory modulation of chemoreflex bradycardia by stimulation of the nucleus raphe obscurus is mediated by 5-HT3 receptors in the NTS of awake rats. Auton Neurosci. 2007 Mar 30; 132(1-2): 27-36. doi: 10.1016/j.autneu.2006.09.002.
2006:
Braga VA, Antunes VR, Machado BH. Autonomic and respiratory responses to microinjection of L-glutamate into the commissural subnucleus of the NTS in the working heart-brainstem preparation of the rat. Brain Res. 2006 Jun 6; 1093(1): 150-60. doi: 10.1016/j.brainres.2006.03.105.
Braga VA, Machado BH. Chemoreflex sympathoexcitation was not altered by the antagonism of glutamate receptors in the commissural nucleus tractus solitarii in the working heart-brainstem preparation of rats. Exp Physiol. 2006 May; 91(3): 551-9. doi: 10.1113/expphysiol.2005.033100.
Braga VA, Soriano RN, Machado BH. Sympathoexcitatory response to peripheral chemoreflex activation is enhanced in juvenile rats exposed to chronic intermittent hypoxia. Exp Physiol. 2006 Nov; 91(6): 1025-31. doi: 10.1113/expphysiol.2006.034868.
Machado BH, Cruz JC, Pajolla GP, Zoccal DB, Braga VA, Accorsi-Mendonça D. Diferentes abordagens experimentais no estudo da modulação da atividade simpática no sistema nervoso central de ratos. Medicina 2006 39: 101-108.
2005:
Antunes VR, Bonagamba LG, Machado BH. Hemodynamic and respiratory responses to microinjection of ATP into the intermediate and caudal NTS of awake rats. Brain Res. 2005 Jan 25; 1032(1-2): 85-93. doi: 10.1016/j.brainres.2004.10.048.
Sevoz-Couche C, Machado BH, Hamon M, Laguzzi R. The Key Role of Medullary 5-HT3 Receptors in the Serotonin-Mediated Neural Control of Cardiovascular Function. Curr Neuropharmacol. 2005; 3(3): 231-248. doi: 10.2174/1570159054368277.
Kellett DO, Stanford SC, Machado BH, Jordan D, Ramage AG. Effect of 5-HT depletion on cardiovascular vagal reflex sensitivity in awake and anesthetized rats. Brain Res. 2005 Aug 23; 1054(1): 61-72. doi: 10.1016/j.brainres.2005.06.063.
Almado CE, Machado BH. Respiratory and autonomic responses to microinjection of NMDA and AMPA into the commissural subnucleus of the NTS of awake rats. Brain Res. 2005 Nov 23; 1063(1): 59-68. doi: 10.1016/j.brainres.2005.09.017.
Antunes VR, Braga VA, Machado BH. Autonomic and respiratory responses to microinjection of ATP into the intermediate or caudal nucleus tractus solitarius in the working heart-brainstem preparation of the rat. Clin Exp Pharmacol Physiol. 2005 May-Jun; 32(5-6): 467-72. doi: 10.1111/j.1440-1681.2005.04213.x.
Machado BH, Bonagamba LG. Antagonism of glutamate receptors in the intermediate and caudal NTS of awake rats produced no changes in the hypertensive response to chemoreflex activation. Auton Neurosci. 2005 Jan 15; 117(1): 25-32. doi: 10.1016/j.autneu.2004.10.004.
Fernandes LG, Antunes VR, Bonagamba LG, Machado BH. Pressor response to chemoreflex activation in awake rats: role of vasopressin and adrenal medulla. Physiol Behav. 2005 Jan 31; 84(1): 39-44. doi: 10.1016/j.physbeh.2004.10.008.
Accorsi-Mendonça D, Almado CEL, Fernandes LG, Machado BH. Controle neural da circulação e hipertensão arterial. Revista Brasileira de Hipertensão 2005 12: 235-241.
2004:
Guimarães JV, Costa RS, Machado BH, dos Reis MA. Cardiovascular profile after intravenous injection of Africanized bee venom in awake rats. Rev Inst Med Trop Sao Paulo. 2004 Jan-Feb; 46(1): 55-8. doi: 10.1590/s0036-46652004000100012.
de Paula PM, Antunes VR, Bonagamba LG, Machado BH. Cardiovascular responses to microinjection of ATP into the nucleus tractus solitarii of awake rats. Am J Physiol Regul Integr Comp Physiol. 2004 Nov; 287(5): R1164-71. doi: 10.1152/ajpregu.00722.2003.
Antunes VR, Bonagamba LG, Machado BH. NMDA receptor antagonism blocks the cardiovascular responses to microinjection of trans-ACPD into the NTS of awake rats. Exp Physiol. 2004 May; 89(3): 279-86. doi: 10.1113/expphysiol.2003.026666.
2003:
Antunes VR, Machado BH. Antagonism of glutamatergic metabotropic receptors in the NTS of awake rats does not affect the gain of the baroreflex. Auton Neurosci. 2003 Jan 31; 103(1-2): 65-71. doi: 10.1016/s1566-0702(02)00234-5.
Pimentel FF, Bonagamba LG, Machado BH. Pressor response to chemoreflex activation before and after microinjection of glycine into the NTS of awake rats. Am J Physiol Regul Integr Comp Physiol. 2003 Apr; 284(4): R1000-9. doi: 10.1152/ajpregu.00310.2002.
Takaoka F, Machado BH. Cardiovascular responses to microinjection of AMPA into the rostral commissural nucleus tractus solitarius of awake rats. Auton Neurosci. 2003 Sep 30; 107(2): 114-9. doi: 10.1016/S1566-0702(03)00131-0.
2002:
Haibara AS, Tamashiro E, Olivan MV, Bonagamba LG, Machado BH. Involvement of the parabrachial nucleus in the pressor response to chemoreflex activation in awake rats. Auton Neurosci. 2002 Oct 31; 101(1-2): 60-7. doi: 10.1016/s1566-0702(02)00210-2.
Barros RC, Bonagamba LG, Okamoto-Canesin R, de Oliveira M, Branco LG, Machado BH. Cardiovascular responses to chemoreflex activation with potassium cyanide or hypoxic hypoxia in awake rats. Auton Neurosci. 2002 May 31; 97(2): 110-5. doi: 10.1016/s1566-0702(02)00050-4.
Machado BH, Bonagamba LG, Dun SL, Kwok EH, Dun NJ. Pressor response to microinjection of orexin/hypocretin into rostral ventrolateral medulla of awake rats. Regul Pept. 2002 Mar 15; 104(1-3):75-81. doi: 10.1016/s0167-0115(01)00351-2.
Reges RV, Bonagamba LG, Nosjean A, Laguzzi R, Machado BH. Involvement of NMDA receptors in the pressor response to microinjection of 5-HT3 agonist into the NTS of awake rats. Auton Neurosci. 2002 Jun 28; 98(1-2): 2-6. doi: 10.1016/s1566-0702(02)00020-6.
Paton JF, De Paula PM, Spyer KM, Machado BH, Boscan P. Sensory afferent selective role of P2 receptors in the nucleus tractus solitarii for mediating the cardiac component of the peripheral chemoreceptor reflex in rats. J Physiol. 2002 Sep 15; 543(Pt 3): 995-1005. doi: 10.1113/jphysiol.2002.021923.
2001:
Machado BH. Neurotransmission of the cardiovascular reflexes in the nucleus tractus solitarii of awake rats. Ann N Y Acad Sci. 2001 Jun; 940: 179-96. doi: 10.1111/j.1749-6632.2001.tb03676.x.
Mauad H, Machado BH. Pressor response to unilateral carotid chemoreceptor activation is not affected by ipsilateral antagonism of excitatory amino acid receptors in the rostral ventrolateral medulla of awake rats. Auton Neurosci. 2001 Aug 13; 91(1-2): 26-31. doi: 10.1016/S1566-0702(01)00297-1.
Olivan MV, Bonagamba LG, Machado BH. Involvement of the paraventricular nucleus of the hypothalamus in the pressor response to chemoreflex activation in awake rats. 2001 Mar 23; 895(1-2): 167-72. doi: 10.1016/s0006-8993(01)02067-4.
Leal DM, Callera JC, Bonagamba LG, Nosjean A, Laguzzi R, Machado BH. Microinjection of a 5-HT3 receptor agonist into the NTS of awake rats inhibits the bradycardic response to activation of the von Bezold-Jarisch reflex. Brain Res Bull. 2001 Jan 1; 54(1): 7-11. doi: 10.1016/s0361-9230(00)00408-1.
de Paula PM, Machado BH. Changes in regional vascular resistance in response to microinjection of L-glutamate into different antero-posterior coordinates of the RVLM in awake rats. Auton Neurosci. 2001 Mar 23; 87(2-3): 301-9. doi: 10.1016/s1566-0702(00)00283-6.
de Paula PM, Machado BH. Antagonism of adenosine A(1) receptors in the NTS does not affect the chemoreflex in awake rats. Am J Physiol Regul Integr Comp Physiol. 2001 Dec; 281(6): R2072-8. doi: 10.1152/ajpregu.2001.281.6.R2072.
2000:
Callera JC, Bonagamba LG, Nosjean A, Laguzzi R, Machado BH. Activation of GABA receptors in the NTS of awake rats reduces the gain of baroreflex bradycardia. Auton Neurosci. 2000 Oct 30; 84(1-2): 58-67. doi: 10.1016/S1566-0702(00)00184-3.
Frigero M, Bonagamba LG, Machado BH. The gain of the baroreflex bradycardia is reduced by microinjection of NMDA receptor antagonists into the nucleus tractus solitarii of awake rats. J Auton Nerv Syst. 2000 Feb 14; 79(1): 28-33. doi: 10.1016/s0165-1838(99)00089-2.
Bonagamba LG, Sévoz-Couche C, N'Diaye A, Uygun-Louvet K, Callera J, Machado BH, Hamon M, Laguzzi R. Bradycardic responses to microinjection of N-methyl-D-aspartate into the nucleus tractus solitarius are inhibited by local activation of 5-HT(3) receptors. Neuropharmacology. 2000 Sep; 39(12): 2336-45. doi: 10.1016/s0028-3908(00)00093-9.
Canesin RO, Bonagamba LG, Machado BH. Bradycardic and hypotensive responses to microinjection of L-glutamate into the lateral aspect of the commissural NTS are blocked by an NMDA receptor antagonist. Brain Res. 2000 Jan 3; 852(1): 68-75. doi: 10.1016/s0006-8993(99)02196-4.
Machado BH, Castania JA, Bonagamba LG, Salgado HC. Neurotransmission of autonomic components of aortic baroreceptor afferents in the NTS of awake rats. Am J Physiol Heart Circ Physiol. 2000 Jul; 279(1): H67-75. doi: 10.1152/ajpheart.2000.279.1.H67.
de Paula PM, Machado BH. Changes in regional vascular resistance in response to microinjection of L-glutamate into different antero-posterior coordinates of the RVLM in awake rats. Auton Neurosci. 2000 Aug 14; 82(3): 137-45. doi: 10.1016/S0165-1838(00)00104-1.
Corrected and republished in: Auton Neurosci. 2001 Mar 23; 87(2-3): 301-9.
Zhang C, Bonagamba LG, Machado BH. Blockade of NK-1 receptors in the lateral commissural nucleus tractus solitarii of awake rats had no effect on the cardiovascular responses to chemoreflex activation. Braz J Med Biol Res. 2000 Nov; 33(11): 1379-85. doi: 10.1590/s0100-879x2000001100018.
